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However, there is a lack of evidence regarding the effectiveness of the Oasis tri-layer matrix. Epicel is indicated to replace the epidermis on severely burned patients. Therefore, FDA considers Epicel a xenotransplantation product.

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It may be used in conjunction with split-thickness autografts, or alone in patients for whom split-thickness autografts may not be an option due to audible alerts for cryptocurrency market severity and extent of their burns. Epicel is indicated for use in a subgroup of the burn population that represents the most severely injured patients.

The FDA granted Epicel its humanitarian use device designation in for the treatment of life-threatening wounds resulting from severe burns.

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Due to the small population for which Epicel is indicated, audible alerts for cryptocurrency market is unlikely there will be sufficient evidence to demonstrate the effectiveness of Epicel for the treatment of burns. The primary benefit of Epicel is that the total number of grafts required to treat a patient can be produced from a single biopsy of unburned skin.

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Patients suffering burns over a significant body surface area can be completely covered regardless of the amount of unburned skin audible alerts for cryptocurrency market for split thickness skin grafts. This minimizes the time to wound closure and minimizes the time in which the patient is most susceptible to serious and potentially life threatening complications.

Epicel is made from a patient's own skin cells and then grown audible alerts for cryptocurrency market a layer of mouse cells to enhance growth. Enough skin can be grown from a biopsy the size of a postage stamp to cover the entire body.

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The process takes approximately 16 days and the skin graft integrates with surrounding tissue 3 to 4 weeks after surgery. Biobrane Mylan Laboratories, Inc. The fabric presents to the wound bed a complex 3-dimensional structure of tri-filament thread to which collagen has been chemically bound.

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Phillips et al reviewed applications of Biobrane on partial skin thickness burn wounds awaiting epithelialization. After the patients had been evaluated and resuscitated as needed, the burn wounds were cleansed and debrided. Those evaluated as shallow were treated with Biobrane application.

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Joint surfaces were splinted for immobilization. The wound was audible alerts for cryptocurrency market at 24 and 48 hours and if any fluid had accumulated it was aspirated and the wound was redressed.

When the Biobrane was adherent, the wound was covered with a light dressing and joint immobilization was discontinued.

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Treatment with Biobrane dressing provided certain advantages over other topical wound care. As the dressing changes were performed less frequently outpatient care was possible, with a resultant decrease in both the length of hospital stay and the ultimate cost of burn care.

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Wound desiccation is prevented and pain is decreased. Accurate diagnosis of wound depth is crucial if Biobrane is to be used.

Very deep wounds will not allow Biobrane adherence, neither will it occur if the wound has a high bacterial count.

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If joint surfaces are not splinted, the Biobrane will shear and not adhere to audible alerts for cryptocurrency market wound. Convex and concave surfaces can be treated with Biobrane, which may need to be meshed. Bishop noted that Biobrane offers a number of advantages as a wound dressing for children.

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It does not require the use of surgical instruments, noisy distractions, painful manipulation of the wound, or regimented daily dressing changes. Biobrane does offer the pediatric patient with burns immediate comfort and protection, and enhances patient compliance and parental satisfaction.

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This is corroborated by the findings of Cassidy et al These researchers compared the effectiveness of Biobrane and Duoderm for the treatment of small intermediate thickness burns in children in a prospective, randomized fashion to determine their relative impact on wound healing, pain scores, and cost. Data collected included mechanism of injury, audible alerts for cryptocurrency market to complete healing, pain scores, and institutional cost of materials until healing source complete.

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The cost of each treatment was statistically more expensive in the Biobrane group. The results of this study showed that Duoderm and Biobrane provide equally effective treatment of partial thickness burns among in the pediatric population.

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Barret et al stated that partial-thickness burns in children have been treated for many years by daily, painful tubbing, washing, and cleansing of the burn wound, followed by topical application of anti-microbial audible alerts for cryptocurrency market. Pain and impaired wound healing are the main problems.

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These investigators audible alerts for cryptocurrency market that the treatment of 2nd-degree burns with Biobrane is superior to topical treatment. The rest of the routine clinical protocols were followed in both groups. Demographic data, wound healing time, length of hospital stay, pain assessments and pain medication requirements, and infection were analyzed and compared.

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Main outcome measures included pain, pain medication requirements, wound healing time, length of hospital stay, and infection. The application of Biobrane to partial-thickness burns proved to be superior to the topical treatment.

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Patients included in the biosynthetic temporary cover group presented with less pain and required less pain medication. Length of hospital stay and wound healing time were also significantly shorter in the Biobrane group.

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None of audible alerts for cryptocurrency market patients in either group presented with wound infection or needed skin autografting. Pain, pain medication requirements, wound healing time, and length of hospital stay are significantly reduced. The most important clinical advantages of both products are prevention of wound desiccation, reduction in pain, reduced dressing changes, and in most reported studies, an acceleration in healing….

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A search in Medline and Embase revealed 51 articles for a critical appraisal. The articles were divided into randomized controlled trials, cohort studies and a group of case-reports.

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Total audible alerts for cryptocurrency market did not differ much among the groups; the level of evidence was highest in the randomized controlled trials and lowest in the case-reports. The competitor dressing was Biobrane in six studies and amnion membrane in three. Tulle gauze, or tulle gauze impregnated with an antibacterial addition were the standard of care treatment in seven studies.

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The authors concluded that, in general, membranous dressings like Biobrane and amnion membrane performed better than the audible alerts for cryptocurrency market of care on epithelialization rate, length of hospital stay and pain for treatment of partial thickness burns in children.

However, hardly any of the studies investigated long-term results like scar formation.

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Austin et al reported on a five year retrospective cohort study evaluating upper extremity burns treated with temporary wound audible alerts for cryptocurrency market Biobrane or cadaveric allograft.

The primary outcome was to determine the impact choice of wound coverage had on operative time and cost. The secondary outcome was the need for revision of upper extremity debridement prior to definitive autografting.

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The investigators found that Biobrane had a significantly lower procedure time Both techniques resulted in 2 revisions due to complications. The investigators concluded audible alerts for cryptocurrency market Biobrane is superior to cadaveric allograft as a temporizing skin https://bat.openrussia.online/617.php in the acute burn wound, both in terms of procedure time and associated cost.

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Primary outcome variables were rate of secondary deepening, surgery, infection defined as positive microbiological swabs and antibiotic treatment and length link stay. Total body surface area TBSA as well as diabetes mellitus DMhypertension, smoking and alcohol consumption as audible alerts for cryptocurrency market confounders were included. Rate of secondary deepening, surgery, infection as well as days of hospital stay DOHS were comparable.

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The investigators concluded that the use of Biobrane in adult scald lesions is safe and non-inferior to topical treatment options. In elder patients and larger TBSA Biobrane may increase the risk of infection or a prolonged stay in hospital.

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AlloDerm Life Cell Corp. AlloDerm is processed from human cadaver skin with the cells responsible for immune response and graft rejection removed.

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The remainder is a matrix or framework of natural biological components, ready to enable the body to mount its own tissue regeneration process. The product has been promoted from the manufacturer for hernia and breast reconstruction.

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Alloderm has been used in the treatment of burn injury. According to the product labeling, "AlloDerm is to be used for repair or replacement of damaged or inadequate integumental tissue or for other homologous uses of human integument.

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During the processing, cells are removed and the product is freeze-dried Snyder, et al. However, there is currently limited evidence to support the use of AlloDerm for wound healing.

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Lattari et al described the use of AlloDerm dermal grafts on 3 patients with full-thickness burns of the distal extremities. Grafts were applied to the hand in 2 cases and the dorsum of the foot in the 3rd case.

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Range of motion, grip strength, fine motor coordination, and functional performance were quantitatively evaluated.

As shown by these patients, cosmetic and functional results were considered good to excellent after the use of AlloDerm grafts with thin autografts.

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Tsai et al presented 12 cases of clinical application of a composite grafting technique in which AlloDerm provided source of dermis, and an ultra-thin autograft 0. In these patients, the composite grafts were applied to full-thickness burn wounds over various articular skin surfaces.

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The average skin graft take rate was These ultra-thin autografts allow the donor sites to heal faster. The mean time of donor site re-epithelization was 6 days.

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Wound assessment over time has shown supple skin that has been resistant to trauma and infection. The cosmetic results were judged to be fair to good by surgeons and patients after 1 year's follow-up.

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Gore stated that because skin thins with advancing age, traditional thickness skin grafts cannot always be obtained in very elderly burn patients without creating a new full-thickness wound at the skin graft donor site. In an attempt to circumvent this problem, AlloDerm and thin autograft depth 0.

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The outcome of patients receiving AlloDerm was compared retrospectively to a similar group of 18 elderly patients admitted over the prior year, 8 of whom underwent operative wound excision and autografting depth 0. Length of hospital stay audible alerts for cryptocurrency market significantly reduced in patients treated with AlloDerm compared to the total group of elderly in whom selective use of operative debridement and skin grafting was used.

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Functional outcome was improved in those patients who underwent skin grafting regardless of operative technique. Unfortunately, 3-month mortality remained poor regardless of operative skin grafting or technique used.

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The authors concluded that these findings suggested that use of AlloDerm may allow more elderly burn patients to undergo operative wound closure, thus improving functional outcome and reducing hospitalization.

Unfortunately, long-term survival for very elderly burn patients remains poor.

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Wound infection and infection of the mesh can be grave complications of hernia repair, often necessitating removal of the mesh and application of a tissue graft. Ventral hernia repair in potentially contaminated or potentially infected fields limit the use of synthetic mesh products.

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Rapid re-vascularization, re-population, and remodeling of the matrix occur on contact with the patient's own tissue. Only limited, and mostly preliminary data, is available on the use of these types of mesh and concerning the potential complications associated with the audible alerts for cryptocurrency market of these types of meshes.

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The investigators reported on the outcomes of 74 patients who underwent ventral hernia repair using these products between June and March Fifteen of the 33 patients treated with AlloDerm developed a diastasis or bulging at the repair site. Explanted material audible alerts for cryptocurrency market separated layers of unincorporated middle layers of the Surgisis mesh.

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Patients also had a significant degree of discomfort and pain during the immediate post-operative period. The investigators concluded that post-operative diastasis and hernia recurrence were a major problem with the AlloDerm mesh.

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The investigators recommended further design improvements in both forms of these new mesh products. Mean follow-up was In the bridged group, 1 patient died on post-operative day The investigators reviewed all patients who underwent repair of massive ventral hernias and identified 7 patients who presented with abdominal wall laxity following component separation with interpositional Alloderm alone.

The investigators reported that all patients developed laxity within 12 months and required a audible alerts for cryptocurrency market procedure.

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At the time of re-exploration, severe attenuation in the Alloderm was noted. The segment was excised, the edges closed primarily, and prolene mesh was placed as an onlay.

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Complications included removal of infected prosthetic mesh in 4 EDAC closure patients; the investigators noted that mesh-related complications had decreased over time. The investigators reported that rates of infection, abdominal wall hematoma, deep venous thrombosis, and pulmonary embolism did audible alerts for cryptocurrency market differ between groups.

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Of 56 patients treated with EDAC, 2 patients had recurrent ventral hernia. The excessive cost of biologic material requires better results than those documented in previous studies.

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The investigators concluded that "polypropylene mesh final EDAC closure risks infection and https://emc.openrussia.online/cap-on-bitcoin.php fistula formation, and long-term follow-up are needed.

Use audible alerts for cryptocurrency market biologic mesh as either final EDAC closure or with vacuum-assisted closure also requires long-term follow-up to justify its increased cost and increased risk of abdominal wall laxity.

Available published evidence regarding the use of Alloderm in breast reconstructive surgery consists primarily of several small case series e.

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There are no comparative studies to determine whether the use of Alloderm improves aesthetic outcomes. The only published comparative study of Alloderm Preminger et al, in breast reconstructive surgery found that Alloderm did not increase the rate of tissue expansion after tissue expander placement.

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Randomized clinical studies are ongoing of Alloderm for tissue expander implant reconstruction and for other audible alerts for cryptocurrency market MSKCC, A thorough search of the Medline database for uses of various biologic grafts in hernia shows that the evidence behind their application is plentiful in some areas ventral, inguinal and nearly absent in others para-stomal. Small intestinal submucosa SIS grafts have an aggregate failure rate of 6.

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Chemically cross-linked grafts have much less published data than the non-cross-linked materials. Furthermore, the cumulative level of evidence for each graft material was fairly low 2.

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Kissane and Itani studied the experience and outcomes of patients who underwent repair of a ventral incisional hernia with biologic mesh. Online database and detailed reference searches were conducted.

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Studies chosen for review had a sample size of at audible alerts for cryptocurrency market 40 patients, level IV evidence at most, and a Methodological Index for Nonrandomized Studies index of at least Indications for use of biologic mesh, type of mesh, patient comorbidities, and surgical techniques were also noted.

A total of 8 studies fulfilled the search criteria and included patients using AlloDerm, Surgisis, and Strattice biologic tissue matrices. In one study, indications and surgical techniques were standardized, and follow-up was prospective.

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In the other 7 studies, indications, surgical techniques, and follow-up were assessed retrospectively. The mean patient age, audible alerts for cryptocurrency market reported, was The authors concluded that biologic tissue matrices are mostly used in contaminated fields, which has allowed for a 1-stage repair with no or little subsequent mesh removal.

Ventral incisional hernia repair with these matrices continues click be plagued by a high recurrence rate and complications.

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They stated that prospective, randomized trials are needed to properly direct practice in the use of these meshes and evaluate their ultimate value. Zeng et al evaluated the precise effectiveness of AlloDerm implants for preventing Frey syndrome after parotidectomy, using a systematic review and meta-analysis. These investigators audible alerts for cryptocurrency market randomized and quasi-randomized controlled trials in which AlloDerm implants were compared to blank controls for preventing Frey syndrome after parotidectomy, from the PubMed, Embase, the Cochrane Library and the ISI Web of Knowledge databases, without any language restriction.

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Two reviewers independently searched, identified, extracted data and assessed methodological quality. Five articles involving patients met the inclusion criteria.

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Adverse events related to AlloDerm implants were not found. There is evidence that AlloDerm reduces the incidence of Frey syndrome effectively audible alerts for cryptocurrency market safely, and also has the potential to improve facial contour and decrease salivary fistula. However, the authors concluded that it is unclear whether AlloDerm implants improve facial contour and decrease other complications; they stated that further controlled evaluative studies incorporating more precise measures are required.

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In a systematic review and meta-analysis, Li et al examined the safety and effectiveness of different types here grafts for the prevention of Frey syndrome after parotidectomy.

The relevant journals and reference lists of the included studies were manually searched for randomized controlled trials RCTs studying the effect and safety of different types of grafts for preventing Frey syndrome after audible alerts for cryptocurrency market.

Aetna considers the following products for wound care medically necessary according to the criteria indicated below:. Aetna considers a culture-derived human skin equivalent HSE called Apligraf graftskin medically necessary for any of the following indications:.

The risk of bias assessment using Cochrane Collaboration's tool and data extraction was independently performed by 2 reviewers. The meta-analysis was performed using Review Manager, version 5.

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A total of 14 RCTs and 1, participants were included. All had an unclear risk of bias.

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No statistically significant difference was found between the acellular dermal matrix and muscle flap groups RR 0. No serious adverse events were reported. The authors concluded that the present clinical evidence suggests that grafts are effective in preventing Frey syndrome after parotidectomy.

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Moreover, they stated that further RCTs are needed to confirm this conclusion and prove the safety of the grafts. Repliform Tissue Regeneration Matrix is audible alerts for cryptocurrency market human acellular dermis. The donor human skin is processed and then freeze-dried to remove cells while maintaining the collagen, elastin, and proteoglycans.

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Repliform is processed by LifeCell Corp. Cymetra Life Cell Corp. Like AlloDerm, Cymetra is made from human allograft skin.

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Because of the small particle size, Cymetra can be delivered by injection as a minimally invasive tissue graft. According to the audible alerts for cryptocurrency market, Cymetra is ideally suited for the correction of soft-tissue defects requiring minimally invasive techniques, such as injection laryngoplasty. The dermal elements from the original pig dermis are likely all deactivated in the chemical process, unlike the frozen pig dermis which is still available.

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It appears that the product is a collagen scaffold. trading cryptocurrency ai amazon.

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Coin / Name Market Cap Dominance Trading Volume Volume / Market Cap Change 24H Price
EMC2 $450,967,486 9.90% 0.0596 -0.74% $5.348795
Brazilian Digital Token $498,965,195 5.36% 0.0591 -0.53% $28.101432
Eidoo $271,824 9.36% 0.0833 +0.82% $35.46071
BIFI $404,409,527 5.62% 0.0934 +0.88% $49.764617
Wirex Token $277,771 3.22% 0.0955 -0.28% $8.238608
SmartMesh $222,967,171 9.60% 0.0255 +0.24% $32.61765
CKB $712,180,160 3.41% 0.0210 -0.53% $6.882359
DAPS $650,576,716 5.21% 0.028 +0.54% $29.746336
Flexacoin $562,136,447 9.84% 0.0485 +0.33% $6.958324
BetaCoin $698,402 7.84% 0.0218 -0.28% $5.975926
BMX $422,661,894 9.89% 0.0718 +0.35% $6.768534
Hdac $681,708,820 3.49% 0.0749 +0.73% $18.454861
Resistance $851,913,664 6.62% 0.0400 -0.27% $10.657906
BlackCoin $740,126,557 9.87% 0.0999 -0.24% $5.965105
ECA $185,701,833 4.61% 0.0100 +0.56% $12.26177
WIN $463,113 1.98% 0.0566 +0.99% $23.295486
Worldwide Asset eXchange $473,365,945 9.74% 0.0726 -0.25% $10.416440
STEEM $532,325 3.68% 0.0277 +0.18% $18.991484
Electroneum $791,751 6.45% 0.0831 -0.11% $4.839301
NEBL $2,851,291 5.62% 0.0911 +0.75% $49.711841
Aidos Kuneen $839,674 9.53% 0.0318 +0.76% $37.459704
Okex $429,814,399 8.64% 0.0385 -0.61% $24.469881
GAS $641,796,227 1.49% 0.0756 -0.98% $8.770743
GazeCoin $493,542 1.59% 0.0339 -0.55% $9.9575
SingularityNET $82,940 1.84% 0.0209 +0.55% $26.871194
INSTAR $306,433,535 9.21% 0.0159 +0.45% $31.383729
Crypterium $301,905 7.24% 0.0341 -0.37% $17.259269
HBT $796,700,337 4.81% 0.0362 -0.85% $10.292229
NEO $229,623,909 6.46% 0.0178 -0.68% $7.21394
KRL $846,981,569 4.76% 0.0123 -0.50% $2.977483
SMART $816,228 6.37% 0.0672 +0.19% $0.40767
CET $287,308 1.52% 0.0753 -0.16% $23.312978
TOPN $620,245 9.39% 0.0904 +0.23% $9.654667
ERK $817,659,126 8.39% 0.0934 +0.49% $3.266731
Dentacoin $64,659 2.16% 0.0548 +0.77% $25.890987
Skrumble Network $48,915 10.81% 0.0266 -0.24% $21.273406
Anchor $473,287,492 4.87% 0.0697 +0.42% $4.830540
Snowgem $283,148 6.91% 0.0126 -0.11% $9.790781
Enjin Coin $141,107 7.65% 0.0772 -0.74% $11.1558
Arepacoin $699,243,122 9.28% 0.0863 +0.21% $2.393378

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